STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0764TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: dra:DR_2575 folyl-polyglutamate synthetase. (433 aa)    
Predicted Functional Partners:
Afer_1911
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.996
Afer_1304
KEGG: ace:Acel_1839 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS.
 
 0.989
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
     
 0.831
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
  
 0.809
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
  
 0.748
Afer_1912
PFAM: GTP cyclohydrolase I; KEGG: paa:Paes_0859 GTP cyclohydrolase I; Belongs to the GTP cyclohydrolase I family.
  
  
 0.746
Afer_1909
TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; KEGG: dra:DR_0170 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.
 
  
 0.706
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.682
Afer_0766
TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; cell division protein FtsA; KEGG: fre:Franean1_5269 cell shape determining protein MreB.
       0.645
Afer_0767
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
       0.642
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.