| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Afer_0535 | Afer_0536 | Afer_0535 | Afer_0536 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | 0.891 |
| Afer_0535 | Afer_0800 | Afer_0535 | Afer_0800 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: rxy:Rxyl_0645 precorrin-8X methylmutase. | 0.981 |
| Afer_0535 | Afer_0802 | Afer_0535 | Afer_0802 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: stp:Strop_2520 precorrin-3B C17- methyltransferase. | 0.999 |
| Afer_0535 | Afer_0804 | Afer_0535 | Afer_0804 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | KEGG: tth:TT_P0002 cob(I)alamin adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. | 0.489 |
| Afer_0535 | Afer_0805 | Afer_0535 | Afer_0805 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: rxy:Rxyl_0638 cobyrinic acid a,c-diamide synthase. | 0.894 |
| Afer_0535 | Afer_0806 | Afer_0535 | Afer_0806 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rxy:Rxyl_0640 precorrin-4 C11- methyltransferase. | 0.980 |
| Afer_0535 | cobD | Afer_0535 | Afer_0538 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.934 |
| Afer_0535 | cobQ | Afer_0535 | Afer_0815 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.949 |
| Afer_0535 | cobS | Afer_0535 | Afer_0537 | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.929 |
| Afer_0536 | Afer_0535 | Afer_0536 | Afer_0535 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.891 |
| Afer_0536 | Afer_0800 | Afer_0536 | Afer_0800 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: rxy:Rxyl_0645 precorrin-8X methylmutase. | 0.538 |
| Afer_0536 | Afer_0802 | Afer_0536 | Afer_0802 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: stp:Strop_2520 precorrin-3B C17- methyltransferase. | 0.693 |
| Afer_0536 | Afer_0804 | Afer_0536 | Afer_0804 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | KEGG: tth:TT_P0002 cob(I)alamin adenosyltransferase; TIGRFAM: cob(I)alamin adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. | 0.964 |
| Afer_0536 | Afer_0805 | Afer_0536 | Afer_0805 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: rxy:Rxyl_0638 cobyrinic acid a,c-diamide synthase. | 0.836 |
| Afer_0536 | Afer_0806 | Afer_0536 | Afer_0806 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rxy:Rxyl_0640 precorrin-4 C11- methyltransferase. | 0.585 |
| Afer_0536 | cobD | Afer_0536 | Afer_0538 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.997 |
| Afer_0536 | cobQ | Afer_0536 | Afer_0815 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.946 |
| Afer_0536 | cobS | Afer_0536 | Afer_0537 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.997 |
| Afer_0536 | hisC | Afer_0536 | Afer_1110 | PFAM: cobalbumin biosynthesis protein; KEGG: nfa:nfa17010 putative cobinamide kinase/cobinamide phosphate guanylyltransferase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: fra:Francci3_3026 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.507 |
| Afer_0800 | Afer_0535 | Afer_0800 | Afer_0535 | PFAM: Precorrin-8X methylmutase CbiC/CobH; KEGG: rxy:Rxyl_0645 precorrin-8X methylmutase. | TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sco:SCO1853 precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.981 |