Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0821TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; ferredoxin; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; KEGG: dge:Dgeo_2746 formate dehydrogenase, alpha subunit. (985 aa)    
Predicted Functional Partners:
Afer_0822
KEGG: sgr:SGR_1901 putative chromosome segregation protein.
  
 
 0.955
Afer_0367
TIGRFAM: NADH-quinone oxidoreductase, E subunit; PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: msm:MSMEG_2059 NADH-quinone oxidoreductase chain E.
  
 
 0.921
Afer_1987
TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mkm:Mkms_5153 glutamate synthase subunit beta.
    
 0.913
Afer_1021
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Polysulphide reductase NrfD; KEGG: nca:Noca_2933 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein.
 
  
 0.890
nuoI
NADH-quinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
 
 0.889
Afer_0834
PFAM: formate dehydrogenase subunit FdhD; KEGG: ttj:TTHB196 putative protein required for formate dehydrogenase activity.
 
 
 
 0.875
Afer_0368
PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: mxa:MXAN_1085 NADH dehydrogenase I, F subunit.
 
 0.867
Afer_0998
PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: sco:SCP1.160c putative oxidoreductase.
 
 
 0.863
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
     
 0.814
Afer_0622
Malate dehydrogenase (oxaloacetate- decarboxylating); PFAM: malic protein NAD-binding; amino acid-binding ACT domain protein; malic protein domain protein; KEGG: nca:Noca_0113 malate dehydrogenase.
    
 0.808
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.