Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_0900PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: rxy:Rxyl_0975 FO synthase. (757 aa)    
Predicted Functional Partners:
Afer_0741
TIGRFAM: LPPG domain protein containing protein; PFAM: protein of unknown function UPF0052 and CofD; KEGG: rxy:Rxyl_0958 LPPG:Fo 2-phospho-L-lactate transferase.
 
  
 0.987
Afer_1154
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.941
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.922
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.917
Afer_0134
Flagellar basal body rod protein; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
    0.837
Afer_1153
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: stp:Strop_3887 thiamine biosynthesis protein ThiS.
  
    0.830
Afer_0899
PFAM: conserved hypothetical protein; KEGG: cya:CYA_0770 hypothetical protein.
       0.826
Afer_0740
TIGRFAM: F420-dependent oxidoreductase; PFAM: protein of unknown function DUF129; KEGG: sco:SCO3037 F420-0--gamma-glutamyl ligase.
 
   
 0.821
Afer_1231
PFAM: NADP oxidoreductase coenzyme F420-dependent; KEGG: fra:Francci3_3151 reduced coenzyme F420:NADP oxidoreductase.
 
     0.780
Afer_0901
6-phosphogluconolactonase/Glucosamine-6-phosphat eisomerase/deaminase-like protein; KEGG: ace:Acel_1122 6-phosphogluconolactonase.
       0.776
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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