node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Afer_0908 | Afer_0913 | Afer_0908 | Afer_0913 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | 0.586 |
Afer_0908 | Afer_1197 | Afer_0908 | Afer_1197 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | KEGG: msm:MSMEG_6365 hypothetical protein. | 0.643 |
Afer_0908 | arc | Afer_0908 | Afer_0907 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.974 |
Afer_0908 | pafA | Afer_0908 | Afer_0912 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.649 |
Afer_0908 | prcA | Afer_0908 | Afer_0911 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.934 |
Afer_0908 | prcB | Afer_0908 | Afer_0910 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.930 |
Afer_0908 | pup | Afer_0908 | Afer_0909 | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.954 |
Afer_0913 | Afer_0908 | Afer_0913 | Afer_0908 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | 0.586 |
Afer_0913 | arc | Afer_0913 | Afer_0907 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.515 |
Afer_0913 | pafA | Afer_0913 | Afer_0912 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.821 |
Afer_0913 | prcA | Afer_0913 | Afer_0911 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.808 |
Afer_0913 | prcB | Afer_0913 | Afer_0910 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.807 |
Afer_0913 | pup | Afer_0913 | Afer_0909 | TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; KEGG: pth:PTH_1717 signal peptidase I; Belongs to the peptidase S26 family. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.616 |
Afer_1197 | Afer_0908 | Afer_1197 | Afer_0908 | KEGG: msm:MSMEG_6365 hypothetical protein. | PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein. | 0.643 |
Afer_1197 | arc | Afer_1197 | Afer_0907 | KEGG: msm:MSMEG_6365 hypothetical protein. | AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.807 |
Afer_1197 | pafA | Afer_1197 | Afer_0912 | KEGG: msm:MSMEG_6365 hypothetical protein. | Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.721 |
Afer_1197 | prcA | Afer_1197 | Afer_0911 | KEGG: msm:MSMEG_6365 hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.984 |
Afer_1197 | prcB | Afer_1197 | Afer_0910 | KEGG: msm:MSMEG_6365 hypothetical protein. | 20S proteasome A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.963 |
Afer_1197 | pup | Afer_1197 | Afer_0909 | KEGG: msm:MSMEG_6365 hypothetical protein. | Protein of unknown function DUF797; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Belongs to the prokaryotic ubiquitin-like protein family. | 0.769 |
Afer_1472 | Afer_1753 | Afer_1472 | Afer_1753 | PFAM: carbohydrate kinase FGGY; KEGG: rsq:Rsph17025_1200 glycerol kinase. | PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: sth:STH1150 hypothetical protein. | 0.954 |