Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0957PFAM: protein of unknown function DUF151; KEGG: sth:STH3179 hypothetical protein. (153 aa)    
Predicted Functional Partners:
Afer_0956
TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein; KEGG: nca:Noca_3461 rod shape-determining protein RodA; Belongs to the SEDS family.
 
     0.816
Afer_1128
PFAM: protein of unknown function DUF151; KEGG: tfu:Tfu_1396 hypothetical protein.
  
     0.545
Afer_0955
Phage shock protein A, PspA; PFAM: PspA/IM30 family protein; KEGG: ace:Acel_0950 phage shock protein A, PspA.
       0.523
Afer_1195
KEGG: scl:sce0507 hypothetical protein.
  
     0.498
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
    0.482
Afer_0459
TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: rxy:Rxyl_0815 inositol-5-monophosphate dehydrogenase.
 
     0.427
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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