STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1092PFAM: ABC-1 domain protein; aminoglycoside phosphotransferase; KEGG: mab:MAB_2393c hypothetical protein. (559 aa)    
Predicted Functional Partners:
Afer_1091
PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: nfa:nfa26120 putative oxidoreductase.
   
   0.789
Afer_1093
6-phosphogluconate dehydrogenase, decarboxylating; KEGG: bxe:Bxe_B1341 6-phosphogluconate dehydrogenase-like protein; TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; 6-phosphogluconate dehydrogenase domain protein.
       0.773
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.707
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
       0.705
trpF
PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: dau:Daud_1187 phosphoribosylanthranilate isomerase; Belongs to the TrpF family.
       0.705
Afer_1097
PFAM: Indole-3-glycerol phosphate synthase; KEGG: bvu:BVU_4091 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family.
       0.705
Afer_1090
Hypothetical protein.
       0.559
Afer_1098
PFAM: major facilitator superfamily MFS_1; KEGG: fal:FRAAL4785 putative mutidrug efflux permease.
       0.472
Afer_1100
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: bha:BH1945 two-component sensor histidine kinase.
   
   0.460
Afer_0027
TIGRFAM: integral membrane protein MviN; PFAM: virulence factor MVIN family protein; multi antimicrobial extrusion protein MatE; KEGG: fal:FRAAL6865 hypothetical protein.
  
     0.423
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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