Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Afer_1128PFAM: protein of unknown function DUF151; KEGG: tfu:Tfu_1396 hypothetical protein. (168 aa)    
Predicted Functional Partners:
Afer_1129
PFAM: cytochrome c biogenesis protein transmembrane region; KEGG: mgm:Mmc1_0245 cytochrome c biogenesis protein, transmembrane region.
       0.608
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
   
    0.561
Afer_0957
PFAM: protein of unknown function DUF151; KEGG: sth:STH3179 hypothetical protein.
  
     0.545
Afer_1127
Hypothetical protein.
       0.535
Afer_1126
Transcriptional regulator, MerR family; PFAM: regulatory protein MerR; SMART: regulatory protein MerR; KEGG: sma:SAV_6982 hypothetical protein.
 
   
 0.483
Afer_1130
PFAM: major facilitator superfamily MFS_1; KEGG: sgr:SGR_469 major facilitator superfamily permease.
       0.439
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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