STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1157PFAM: Prephenate dehydrogenase; KEGG: krh:KRH_15220 prephenate dehydrogenase. (324 aa)    
Predicted Functional Partners:
Afer_1158
PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: bvi:Bcep1808_0964 chorismate mutase / prephenate dehydratase.
 
 
 0.984
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: fra:Francci3_3026 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 
 0.981
pheA
PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: ade:Adeh_1779 prephenate dehydratase.
 
 
 0.974
Afer_1355
TIGRFAM: chorismate mutase; PFAM: Chorismate mutase of the AroH class; KEGG: nca:Noca_2499 chorismate mutase.
  
 
  0.934
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.933
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.907
Afer_1531
PFAM: aminotransferase class I and II; KEGG: rsa:RSal33209_0984 aspartate aminotransferase.
  
 
 0.907
Afer_1717
PFAM: 3-dehydroquinate synthase; KEGG: saq:Sare_1253 3-dehydroquinate synthase.
 
  
 0.887
Afer_0624
PFAM: integrase family protein; integrase domain protein SAM domain protein; KEGG: sew:SeSA_A4159 tyrosine recombinase XerC.
  
    0.734
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
  
 0.732
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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