Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1202PFAM: Aldehyde Dehydrogenase; KEGG: aau:AAur_1331 putative succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (487 aa)    
Predicted Functional Partners:
Afer_0700
PFAM: aminotransferase class-III; KEGG: rca:Rcas_3219 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.930
Afer_0312
KEGG: sgr:SGR_2689 putative succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; succinate dehydrogenase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase.
   
 0.921
Afer_0313
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: fal:FRAAL1187 succinate dehydrogenase iron- sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
   
 
 0.908
Afer_0188
TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: kra:Krad_3952 succinate dehydrogenase cytochrome b556 subunit.
   
 
  0.905
Afer_0187
KEGG: fra:Francci3_0680 succinate dehydrogenase subunit D.
   
 
 0.904
fumC
Fumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.889
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.876
Afer_1835
KEGG: fre:Franean1_7227 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.866
Afer_2022
KEGG: msm:MSMEG_4035 citrate synthase.
  
 0.865
Afer_1881
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: afl:Aflv_0505 isocitrate dehydrogenase.
   
 0.862
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.