Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1228PFAM: histidine triad (HIT) protein; KEGG: sus:Acid_4300 histidine triad (HIT) protein. (163 aa)    
Predicted Functional Partners:
thrS
KEGG: fal:FRAAL5168 threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase SAD; Belongs to the class-II aminoacyl-tRNA synthetase family.
    
 0.952
Afer_1230
Cysteine--tRNA ligase; PFAM: Cysteinyl-tRNA synthetase class Ia; tRNA synthetase class I (M); KEGG: sma:SAV_6647 cysteinyl-tRNA synthetase.
       0.822
Afer_1231
PFAM: NADP oxidoreductase coenzyme F420-dependent; KEGG: fra:Francci3_3151 reduced coenzyme F420:NADP oxidoreductase.
       0.817
Afer_1232
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sen:SACE_3786 enoyl-(acyl carrier protein) reductase.
       0.567
Afer_1233
Hypothetical protein; KEGG: predicted gene, 100039767.
       0.417
Afer_1224
PFAM: lipid A biosynthesis acyltransferase; KEGG: tfu:Tfu_2102 lipid A biosynthesis lauroyl acyltransferase.
  
  
 0.414
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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