STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1235Apurinic endonuclease Apn1; KEGG: tfu:Tfu_1956 endonuclease IV; TIGRFAM: apurinic endonuclease Apn1; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2. (278 aa)    
Predicted Functional Partners:
Afer_1727
TIGRFAM: exodeoxyribonuclease III Xth; exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: ace:Acel_1469 exodeoxyribonuclease III.
    
 
 0.879
Afer_1234
PFAM: Pirin domain protein; KEGG: ace:Acel_1948 pirin domain-containing protein; Belongs to the pirin family.
       0.697
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.626
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.595
Afer_0806
PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rxy:Rxyl_0640 precorrin-4 C11- methyltransferase.
      
 0.506
Afer_0472
PFAM: peptidase U62 modulator of DNA gyrase; KEGG: hmo:HM1_0268 modulator of DNA gyrase, putative.
      
 0.504
Afer_0712
TIGRFAM: HhH-GPD family protein; PFAM: HhH-GPD family protein; KEGG: sma:SAV_4172 hypothetical protein.
  
 
 0.502
Afer_1236
PFAM: DivIVA family protein; KEGG: nfa:nfa17740 hypothetical protein.
       0.495
Afer_1467
PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; KEGG: ace:Acel_0968 hypothetical protein.
     
 0.462
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.451
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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