Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Afer_1254PFAM: biotin/lipoate A/B protein ligase; KEGG: cau:Caur_3882 biotin/lipoate A/B protein ligase. (218 aa)    
Predicted Functional Partners:
lipB
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the LipB family.
  
 0.951
Afer_0577
KEGG: oih:OB1441 hypothetical protein.
  
     0.588
Afer_0346
KEGG: saq:Sare_3145 transcriptional regulator, TrmB.
  
     0.568
Afer_1732
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; KEGG: ace:Acel_0586 alpha-ketoglutarate decarboxylase.
  
 0.560
Afer_1292
PFAM: protein of unknown function DUF558; KEGG: afw:Anae109_0268 hypothetical protein.
 
    0.547
Afer_1255
PFAM: regulatory protein AsnC/Lrp family; KEGG: sma:SAV_2677 hypothetical protein.
       0.536
rsmH
S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
  
   0.523
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
 
     0.472
Afer_0828
PFAM: conserved hypothetical protein; KEGG: rxy:Rxyl_2377 conserved hypothetical protein 374.
  
     0.458
gcvH
Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 0.457
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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