STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1291PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: fre:Franean1_2773 XRE family transcriptional regulator. (194 aa)    
Predicted Functional Partners:
Afer_1290
KEGG: ace:Acel_0781 coproporphyrinogen III oxidase, anaerobic; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB.
       0.803
Afer_1289
Hypothetical protein.
       0.768
Afer_1292
PFAM: protein of unknown function DUF558; KEGG: afw:Anae109_0268 hypothetical protein.
 
     0.745
Afer_1105
Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family.
  
   
 0.730
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
     
 0.682
Afer_1459
KEGG: stp:Strop_0704 hypothetical protein.
  
     0.675
Afer_1140
PFAM: major facilitator superfamily MFS_1; KEGG: rxy:Rxyl_2414 major facilitator superfamily MFS_1.
  
     0.645
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.635
Afer_0039
KEGG: ace:Acel_2136 hypothetical protein.
  
     0.608
Afer_0355
Superoxide dismutase, Ni; KEGG: ace:Acel_0566 superoxide dismutase; TIGRFAM: superoxide dismutase, Ni; PFAM: Superoxide dismutase Ni-type.
  
     0.589
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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