Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_1346Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: saq:Sare_0033 propionyl-CoA carboxylase. (508 aa)    
Predicted Functional Partners:
Afer_0730
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: kra:Krad_3912 carbamoyl-phosphate synthase L chain ATP-binding.
 
 0.994
Afer_1032
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; phosphoribosylglycinamide synthetase; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: fal:FRAAL1668 acetyl-/propionyl-coenzyme A carboxylase alpha chain.
 
 0.985
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
  
 0.757
Afer_0106
KEGG: fal:FRAAL5910 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.752
Afer_0261
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: tfu:Tfu_0436 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.752
der
Small GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
       0.747
Afer_1348
PFAM: protein of unknown function DUF512; KEGG: syw:SYNW2188 Fe-S oxidoreductase.
       0.747
Afer_0289
PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nfa:nfa50130 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.700
Afer_1344
PFAM: beta-lactamase domain protein; KEGG: sma:SAV_6616 polyketide cyclase.
  
    0.665
Afer_1286
TIGRFAM: acetate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: ace:Acel_1984 acetyl-coenzyme A synthetase.
  
 
 0.664
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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