Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
Experiments
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[Homology]
Score
Afer_1363PFAM: short-chain dehydrogenase/reductase SDR; NAD- dependent epimerase/dehydratase; KEGG: afw:Anae109_1109 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa)    
Predicted Functional Partners:
Afer_0679
PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: afw:Anae109_3740 threonine aldolase.
    
 0.917
Afer_1367
PFAM: AMP-dependent synthetase and ligase; KEGG: abo:ABO_0184 long-chain-fatty-acid-CoA ligase, putative.
 
  
 0.869
Afer_1118
Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: tte:TTE0293 glycine dehydrogenase subunit 2.
 
      0.699
gcvPA
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
      0.624
Afer_1361
PFAM: FAD linked oxidase domain protein; KEGG: cyb:CYB_2695 FAD-binding protein.
  
    0.573
Afer_1362
PFAM: FAD linked oxidase domain protein; KEGG: sen:SACE_6366 glycolate oxidase subunit.
  
    0.573
Afer_1360
PFAM: protein of unknown function DUF224 cysteine- rich region domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: ank:AnaeK_2951 protein of unknown function DUF224 cysteine-rich region domain protein.
       0.560
Afer_1364
PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: pac:PPA0955 deoxyguanosinetriphosphate triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily.
       0.493
Afer_1359
PFAM: GCN5-related N-acetyltransferase; KEGG: mxa:MXAN_3222 acetyltransferase, GNAT family.
       0.486
Afer_1365
PFAM: transcriptional regulator PadR family protein; KEGG: sgr:SGR_6165 PadR-like family transcriptional regulator.
 
     0.485
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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