STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1460PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicases; helicase domain protein; KEGG: dau:Daud_0816 DEAD/DEAH box helicase domain- containing protein. (766 aa)    
Predicted Functional Partners:
Afer_1457
PFAM: Methyltransferase type 12; Methyltransferase type 11; KEGG: sco:SCO3340 hypothetical protein.
       0.773
Afer_1458
PFAM: Amidase; KEGG: sen:SACE_2834 secreted amidase.
       0.773
Afer_1459
KEGG: stp:Strop_0704 hypothetical protein.
       0.773
Afer_1456
Hypothetical protein; KEGG: bpa:BPP4333 putative integral membrane protein.
       0.697
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.573
Afer_2034
PFAM: single-stranded nucleic acid binding R3H domain protein; SMART: single-stranded nucleic acid binding R3H domain protein; KEGG: efa:EF3330 jag protein, putative.
  
   
 0.501
Afer_1455
PFAM: aldo/keto reductase; KEGG: bac:BamMC406_2130 aldo/keto reductase.
       0.467
purC
PFAM: SAICAR synthetase; KEGG: mva:Mvan_5138 phosphoribosylaminoimidazole- succinocarboxamide synthase.
  
     0.420
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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