STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1467PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; KEGG: ace:Acel_0968 hypothetical protein. (475 aa)    
Predicted Functional Partners:
Afer_1303
KEGG: rha:RHA1_ro01286 DNA polymerase III delta subunit.
    
 0.962
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
  
 
 0.959
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.956
Afer_0002
KEGG: rxy:Rxyl_0002 DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta chain; SMART: DNA polymerase III beta chain.
   
 0.954
Afer_1638
KEGG: ace:Acel_1054 DNA polymerase III subunit alpha; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein.
    
 0.953
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.844
Afer_0652
TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; KEGG: fal:FRAAL5732 competence-inducible (CinA- like) protein; Belongs to the CinA family.
  
  
 0.839
Afer_0668
SOS-response transcriptional repressor, LexA; KEGG: nfa:nfa38000 LexA repressor; TIGRFAM: LexA repressor; PFAM: LexA DNA-binding domain protein; peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family.
  
  
 0.735
pgk
PFAM: phosphoglycerate kinase; KEGG: rxy:Rxyl_2004 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
   
 0.732
Afer_1612
KEGG: fal:FRAAL2179 putative DNA-directed DNA polymerase.
 
  
 0.729
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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