STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (338 aa)    
Predicted Functional Partners:
Afer_1831
Protoporphyrinogen oxidase; KEGG: ace:Acel_1381 UDP-galactopyranose mutase; TIGRFAM: protoporphyrinogen oxidase; PFAM: amine oxidase; FAD dependent oxidoreductase.
 
 0.996
Afer_1843
PFAM: Chlorite dismutase; KEGG: ttj:TTHA1714 putative heme peroxidase.
 
 
 0.983
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.962
Afer_0817
KEGG: nfa:nfa40830 putative magnesium chelatase subunit; PFAM: ATPase associated with various cellular activities AAA_5; AAA ATPase central domain protein; von Willebrand factor type A; magnesium chelatase ChlI subunit; SMART: von Willebrand factor type A; AAA ATPase.
  
 
 0.953
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.931
Afer_0311
KEGG: fra:Francci3_3905 magnesium chelatase, ChlI subunit.
  
 
 0.922
Afer_0127
PFAM: Ferritin Dps family protein; KEGG: afe:Lferr_1380 ferritin Dps family protein.
     
 0.917
Afer_1148
PFAM: Radical SAM domain protein; KEGG: nca:Noca_1430 radical SAM domain-containing protein.
  
 
 0.914
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
  
 0.817
rpmB
TIGRFAM: ribosomal protein L28; PFAM: ribosomal protein L28; KEGG: fre:Franean1_1131 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
  
    0.775
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.