Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Afer_1614Transcriptional regulator, GntR family; PFAM: UbiC transcription regulator-associated domain protein; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; KEGG: dsy:DSY4747 hypothetical protein. (250 aa)    
Predicted Functional Partners:
Afer_0274
Transcriptional regulator, XRE family; PFAM: Cupin 2 conserved barrel domain protein; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: art:Arth_0847 transcriptional regulator, XRE family with cupin sensor.
 
  
 0.713
Afer_1326
PFAM: GntR domain protein; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; KEGG: msm:MSMEG_2682 transcriptional regulator.
  
  
 0.699
dnaE2
DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.
       0.682
Afer_1612
KEGG: fal:FRAAL2179 putative DNA-directed DNA polymerase.
       0.682
Afer_1613
KEGG: cur:cur_0403 hypothetical protein.
       0.682
Afer_1610
Hypothetical protein; KEGG: GK23692.
       0.624
Afer_0346
KEGG: saq:Sare_3145 transcriptional regulator, TrmB.
   
  
 0.555
Afer_2008
Transcriptional regulator, MerR family; PFAM: Transcription regulator MerR DNA binding; regulatory protein MerR; SMART: regulatory protein MerR; KEGG: nca:Noca_1646 MerR family transcriptional regulator.
  
  
 0.529
Afer_1609
PFAM: LmbE family protein; KEGG: sen:SACE_0909 N- acetylglucosaminylphosphatidylinositol deacetylase.
       0.497
Afer_1608
Hypothetical protein; KEGG: csa:Csal_1939 sterol-binding.
       0.494
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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