Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_1827PFAM: cytochrome c class I; KEGG: fre:Franean1_1810 cytochrome c class I. (280 aa)    
Predicted Functional Partners:
Afer_1826
PFAM: Rieske [2Fe-2S] domain protein; KEGG: fal:FRAAL5110 ubiquinol-cytochrome c reductase iron-sulfur subunit (Rieske iron-sulfur protein).
 
  
 0.996
Afer_1825
PFAM: Cytochrome b/b6 domain; KEGG: fre:Franean1_1812 cytochrome b/b6 domain- containing protein.
 
  
 0.995
Afer_1822
Hypothetical protein; KEGG: fal:FRAAL5121 putative integral membrane protein.
 
     0.912
Afer_1828
PFAM: cytochrome c oxidase subunit III; KEGG: mjl:Mjls_3302 cytochrome c oxidase, subunit III.
 
  
 0.865
Afer_1824
Cytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 
   
 0.863
Afer_1823
Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
     
 0.794
Afer_0340
PFAM: oxidoreductase molybdopterin binding; KEGG: rca:Rcas_2793 oxidoreductase molybdopterin binding.
   
 
 0.786
Afer_0193
PFAM: cytochrome oxidase assembly; KEGG: fra:Francci3_1653 cytochrome oxidase assembly.
 
     0.753
Afer_1131
KEGG: sco:SCO1215 integral membrane protein.
  
     0.744
Afer_1829
KEGG: sen:SACE_5730 ATP-dependent DNA helicase.
       0.669
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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