Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1841KEGG: scl:sce5850 hypothetical protein. (265 aa)    
Predicted Functional Partners:
Afer_0098
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; KEGG: mrd:Mrad2831_1356 putative circadian phase modifier CpmA-like protein.
  
 0.980
Afer_0099
PFAM: protein of unknown function DUF111; KEGG: mem:Memar_2158 hypothetical protein.
  
 0.964
Afer_1430
KEGG: nca:Noca_2000 hypothetical protein.
 
  
 0.812
Afer_1840
Ferredoxin; KEGG: tye:THEYE_A1680 ferredoxin.
       0.787
Afer_1839
Hypothetical protein.
       0.773
Afer_1555
PFAM: tRNA (5-methylaminomethyl-2-thiouridylate)- methyltransferase; ExsB family protein; KEGG: scl:sce7297 tRNA (5-methylaminomethyl-2- thiouridylate)-methyltransferase.
    
 0.744
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.726
Afer_1306
PFAM: aldo/keto reductase; KEGG: nca:Noca_0658 aldo/keto reductase.
 
    0.544
Afer_1842
PFAM: transposase IS4 family protein; KEGG: mva:Mvan_4071 transposase, IS4 family protein.
       0.427
Afer_1838
PFAM: NUDIX hydrolase; KEGG: mxa:MXAN_5418 hydrolase, NUDIX family.
  
    0.407
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.