STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1922PFAM: nucleic acid binding OB-fold tRNA/helicase- type; amino acid permease-associated region; KEGG: ace:Acel_1194 nucleic acid binding, OB-fold, tRNA/helicase-type. (777 aa)    
Predicted Functional Partners:
Afer_1923
PFAM: TrkA-N domain protein; KEGG: sgr:SGR_1656 putative potassium transporter.
 
   
 0.748
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
    0.734
Afer_1924
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: fre:Franean1_5192 TrkA domain-containing protein.
 
   
 0.713
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
       0.706
Afer_0378
PFAM: protein of unknown function DUF470; protein of unknown function DUF472; protein of unknown function DUF471; KEGG: sma:SAV_4673 hypothetical protein.
  
     0.546
Afer_1925
TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: stp:Strop_4041 HAD family hydrolase.
   
   0.458
Afer_1328
PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: bra:BRADO0511 alpha-glucosidase.
   
 0.401
Afer_1778
KEGG: fal:FRAAL5900 trehalose synthase (maltose alpha-D-glucosyltransferase); TIGRFAM: trehalose synthase; PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain.
   
 0.401
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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