STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_1983PFAM: aminotransferase class-III; KEGG: nca:Noca_3921 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)    
Predicted Functional Partners:
Afer_0252
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: krh:KRH_08550 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.977
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.970
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: dol:Dole_1545 glutamate-1-semialdehyde-2,1- aminomutase.
  
  
 
0.925
Afer_0251
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: sus:Acid_3181 uroporphyrinogen-III C- methyltransferase / uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family.
 
  
 0.757
Afer_0250
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.756
Afer_1988
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: ace:Acel_1078 glutamate synthase (NADH) large subunit.
     
 0.646
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.598
Afer_1981
Two component transcriptional regulator, LuxR family; PFAM: response regulator receiver; regulatory protein LuxR; Bacterio-opsin activator HTH domain protein; SMART: regulatory protein LuxR; response regulator receiver; KEGG: cms:CMS_0994 putative two-component system response regulator.
       0.553
Afer_1982
Putative signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; KEGG: kra:Krad_1351 integral membrane sensor signal transduction histidine kinase.
       0.553
Afer_1129
PFAM: cytochrome c biogenesis protein transmembrane region; KEGG: mgm:Mmc1_0245 cytochrome c biogenesis protein, transmembrane region.
  
  
 0.528
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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