node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDZ84704.1 | SEA93413.1 | SAMN05660964_00387 | SAMN05660964_02863 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase (ferredoxin). | 0.441 |
SDZ84704.1 | SEB02752.1 | SAMN05660964_00387 | SAMN05660964_03195 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase. | 0.496 |
SDZ84704.1 | folD | SAMN05660964_00387 | SAMN05660964_03584 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.845 |
SDZ84704.1 | gcvP | SAMN05660964_00387 | SAMN05660964_03204 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.496 |
SDZ84704.1 | gcvT | SAMN05660964_00387 | SAMN05660964_03206 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.849 |
SDZ84704.1 | glyA | SAMN05660964_00387 | SAMN05660964_00840 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
SDZ84704.1 | purH | SAMN05660964_00387 | SAMN05660964_03404 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.658 |
SDZ84704.1 | purN | SAMN05660964_00387 | SAMN05660964_01411 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.664 |
SEA93413.1 | SDZ84704.1 | SAMN05660964_02863 | SAMN05660964_00387 | Glutamate synthase (ferredoxin). | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.441 |
SEA93413.1 | SEB02752.1 | SAMN05660964_02863 | SAMN05660964_03195 | Glutamate synthase (ferredoxin). | Glycine dehydrogenase. | 0.980 |
SEA93413.1 | folD | SAMN05660964_02863 | SAMN05660964_03584 | Glutamate synthase (ferredoxin). | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.494 |
SEA93413.1 | gcvH | SAMN05660964_02863 | SAMN05660964_03205 | Glutamate synthase (ferredoxin). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.956 |
SEA93413.1 | gcvP | SAMN05660964_02863 | SAMN05660964_03204 | Glutamate synthase (ferredoxin). | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.980 |
SEA93413.1 | gcvT | SAMN05660964_02863 | SAMN05660964_03206 | Glutamate synthase (ferredoxin). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |
SEA93413.1 | glyA | SAMN05660964_02863 | SAMN05660964_00840 | Glutamate synthase (ferredoxin). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
SEA93413.1 | purH | SAMN05660964_02863 | SAMN05660964_03404 | Glutamate synthase (ferredoxin). | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.952 |
SEA93413.1 | purL | SAMN05660964_02863 | SAMN05660964_02141 | Glutamate synthase (ferredoxin). | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.961 |
SEB02752.1 | SDZ84704.1 | SAMN05660964_03195 | SAMN05660964_00387 | Glycine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.496 |
SEB02752.1 | SEA93413.1 | SAMN05660964_03195 | SAMN05660964_02863 | Glycine dehydrogenase. | Glutamate synthase (ferredoxin). | 0.980 |
SEB02752.1 | folD | SAMN05660964_03195 | SAMN05660964_03584 | Glycine dehydrogenase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.672 |