node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEA40527.1 | SEA56805.1 | SAMN05660964_01515 | SAMN05660964_01912 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Acetolactate synthase, small subunit. | 0.782 |
SEA40527.1 | SEA56827.1 | SAMN05660964_01515 | SAMN05660964_01913 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Acetolactate synthase, large subunit. | 0.859 |
SEA40527.1 | SEA73191.1 | SAMN05660964_01515 | SAMN05660964_02285 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.852 |
SEA40527.1 | SEA92074.1 | SAMN05660964_01515 | SAMN05660964_02834 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.987 |
SEA40527.1 | SEB00521.1 | SAMN05660964_01515 | SAMN05660964_03115 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | acyl-CoA dehydrogenase. | 0.578 |
SEA40527.1 | ilvA | SAMN05660964_01515 | SAMN05660964_00126 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.428 |
SEA40527.1 | ilvC | SAMN05660964_01515 | SAMN05660964_01911 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.435 |
SEA40527.1 | ilvD | SAMN05660964_01515 | SAMN05660964_02837 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.550 |
SEA40527.1 | leuA-2 | SAMN05660964_01515 | SAMN05660964_03311 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.773 |
SEA40527.1 | leuB | SAMN05660964_01515 | SAMN05660964_03151 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.420 |
SEA56805.1 | SEA40527.1 | SAMN05660964_01912 | SAMN05660964_01515 | Acetolactate synthase, small subunit. | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | 0.782 |
SEA56805.1 | SEA56827.1 | SAMN05660964_01912 | SAMN05660964_01913 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SEA56805.1 | SEA73191.1 | SAMN05660964_01912 | SAMN05660964_02285 | Acetolactate synthase, small subunit. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.534 |
SEA56805.1 | SEA92074.1 | SAMN05660964_01912 | SAMN05660964_02834 | Acetolactate synthase, small subunit. | Pyruvate-ferredoxin/flavodoxin oxidoreductase. | 0.963 |
SEA56805.1 | ilvA | SAMN05660964_01912 | SAMN05660964_00126 | Acetolactate synthase, small subunit. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.980 |
SEA56805.1 | ilvC | SAMN05660964_01912 | SAMN05660964_01911 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SEA56805.1 | ilvD | SAMN05660964_01912 | SAMN05660964_02837 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.896 |
SEA56805.1 | leuA-2 | SAMN05660964_01912 | SAMN05660964_03311 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.935 |
SEA56805.1 | leuB | SAMN05660964_01912 | SAMN05660964_03151 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.980 |
SEA56827.1 | SEA40527.1 | SAMN05660964_01913 | SAMN05660964_01515 | Acetolactate synthase, large subunit. | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). | 0.859 |