Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Apre_0273PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: sfu:Sfum_0842 thiamine biosynthesis protein ThiH. (472 aa)    
Predicted Functional Partners:
Apre_0272
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; KEGG: sfu:Sfum_1843 small GTP-binding protein.
  
 0.982
Apre_1632
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.980
Apre_1631
TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: cha:CHAB381_1176 thiamine biosynthesis protein ThiH.
  
  
 
0.921
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.763
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.762
Apre_1634
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: cff:CFF8240_0073 thiamine biosynthesis protein ThiS.
  
    0.717
Apre_0007
Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: bce:BC1002 anti-sigma B factor antagonist; Belongs to the anti-sigma-factor antagonist family.
  
    0.702
Apre_0008
Putative anti-sigma regulatory factor, serine/threonine protein kinase; KEGG: bca:BCE_1085 serine-protein kinase RsbW.
   
    0.698
Apre_1539
PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein; KEGG: spl:Spea_0302 response regulator receiver modulated serine phosphatase.
   
    0.698
Apre_1085
TIGRFAM: hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; 4Fe-4S ferredoxin iron- sulfur binding domain protein; ferredoxin; KEGG: pca:Pcar_1633 NAD-reducing iron-only hydrogenase large subunit.
 
   
 0.572
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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