| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0188 | Apre_0442 | Apre_0188 | Apre_0442 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | 0.918 |
| Apre_0188 | Apre_0550 | Apre_0188 | Apre_0550 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | 0.936 |
| Apre_0188 | glsA | Apre_0188 | Apre_0305 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | 0.913 |
| Apre_0188 | murI | Apre_0188 | Apre_0492 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.849 |
| Apre_0442 | Apre_0188 | Apre_0442 | Apre_0188 | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.918 |
| Apre_0442 | Apre_0550 | Apre_0442 | Apre_0550 | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | 0.911 |
| Apre_0442 | glsA | Apre_0442 | Apre_0305 | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | 0.900 |
| Apre_0442 | murI | Apre_0442 | Apre_0492 | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.811 |
| Apre_0493 | ispE | Apre_0493 | Apre_0491 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.793 |
| Apre_0493 | murI | Apre_0493 | Apre_0492 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.788 |
| Apre_0493 | ppk | Apre_0493 | Apre_0494 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.972 |
| Apre_0550 | Apre_0188 | Apre_0550 | Apre_0188 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.936 |
| Apre_0550 | Apre_0442 | Apre_0550 | Apre_0442 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | 0.911 |
| Apre_0550 | glsA | Apre_0550 | Apre_0305 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | 0.911 |
| Apre_0550 | murI | Apre_0550 | Apre_0492 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.800 |
| Apre_0898 | murI | Apre_0898 | Apre_0492 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.917 |
| Apre_1404 | murI | Apre_1404 | Apre_0492 | KEGG: bcy:Bcer98_3299 alanine dehydrogenase; TIGRFAM: alanine dehydrogenase; PFAM: alanine dehydrogenase/PNT domain protein; D- isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Belongs to the AlaDH/PNT family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.802 |
| glsA | Apre_0188 | Apre_0305 | Apre_0188 | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.913 |
| glsA | Apre_0442 | Apre_0305 | Apre_0442 | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | PFAM: glutamine synthetase catalytic region; KEGG: sat:SYN_01613 glutamine synthetase. | 0.900 |
| glsA | Apre_0550 | Apre_0305 | Apre_0550 | PFAM: Glutaminase, core; KEGG: Glutaminase family protein; K01425 glutaminase; Belongs to the glutaminase family. | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | 0.911 |