| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0493 | Apre_0910 | Apre_0493 | Apre_0910 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.925 |
| Apre_0493 | Apre_1576 | Apre_0493 | Apre_1576 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | 0.664 |
| Apre_0493 | guaB | Apre_0493 | Apre_1106 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.435 |
| Apre_0493 | ispE | Apre_0493 | Apre_0491 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.793 |
| Apre_0493 | murI | Apre_0493 | Apre_0492 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.788 |
| Apre_0493 | ppk | Apre_0493 | Apre_0494 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.972 |
| Apre_0910 | Apre_0493 | Apre_0910 | Apre_0493 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.925 |
| Apre_0910 | guaB | Apre_0910 | Apre_1106 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.815 |
| Apre_1576 | Apre_0493 | Apre_1576 | Apre_0493 | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.664 |
| Apre_1576 | ppk | Apre_1576 | Apre_0494 | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.817 |
| guaB | Apre_0493 | Apre_1106 | Apre_0493 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.435 |
| guaB | Apre_0910 | Apre_1106 | Apre_0910 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.815 |
| ispE | Apre_0493 | Apre_0491 | Apre_0493 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.793 |
| ispE | murI | Apre_0491 | Apre_0492 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.808 |
| ispE | ppk | Apre_0491 | Apre_0494 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.797 |
| murI | Apre_0493 | Apre_0492 | Apre_0493 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.788 |
| murI | ispE | Apre_0492 | Apre_0491 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.808 |
| murI | ppk | Apre_0492 | Apre_0494 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.788 |
| ppk | Apre_0493 | Apre_0494 | Apre_0493 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.972 |
| ppk | Apre_1576 | Apre_0494 | Apre_1576 | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | 0.817 |