| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0395 | Apre_0677 | Apre_0395 | Apre_0677 | Inorganic diphosphatase; KEGG: pca:Pcar_1659 putative manganese-dependent inorganic pyrophosphatase; PFAM: DHHA2 domain protein; CBS domain containing protein; DRTGG domain protein; SMART: CBS domain containing protein. | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: bha:BH3163 pyruvate kinase; Belongs to the pyruvate kinase family. | 0.474 |
| Apre_0395 | ppk | Apre_0395 | Apre_0494 | Inorganic diphosphatase; KEGG: pca:Pcar_1659 putative manganese-dependent inorganic pyrophosphatase; PFAM: DHHA2 domain protein; CBS domain containing protein; DRTGG domain protein; SMART: CBS domain containing protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.900 |
| Apre_0429 | ppk | Apre_0429 | Apre_0494 | PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; KEGG: bcr:BCAH187_A1350 cardiolipin synthetase; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.680 |
| Apre_0493 | Apre_1576 | Apre_0493 | Apre_1576 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | 0.688 |
| Apre_0493 | ispE | Apre_0493 | Apre_0491 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.791 |
| Apre_0493 | murI | Apre_0493 | Apre_0492 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.789 |
| Apre_0493 | polA | Apre_0493 | Apre_1330 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.437 |
| Apre_0493 | ppk | Apre_0493 | Apre_0494 | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.986 |
| Apre_0677 | Apre_0395 | Apre_0677 | Apre_0395 | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: bha:BH3163 pyruvate kinase; Belongs to the pyruvate kinase family. | Inorganic diphosphatase; KEGG: pca:Pcar_1659 putative manganese-dependent inorganic pyrophosphatase; PFAM: DHHA2 domain protein; CBS domain containing protein; DRTGG domain protein; SMART: CBS domain containing protein. | 0.474 |
| Apre_0677 | ppk | Apre_0677 | Apre_0494 | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: bha:BH3163 pyruvate kinase; Belongs to the pyruvate kinase family. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.434 |
| Apre_1576 | Apre_0493 | Apre_1576 | Apre_0493 | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.688 |
| Apre_1576 | ppk | Apre_1576 | Apre_0494 | PFAM: protein of unknown function DUF344; KEGG: pfl:PFL_4331 hypothetical protein. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.832 |
| ispE | Apre_0493 | Apre_0491 | Apre_0493 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.791 |
| ispE | murI | Apre_0491 | Apre_0492 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.804 |
| ispE | ppk | Apre_0491 | Apre_0494 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.802 |
| murI | Apre_0493 | Apre_0492 | Apre_0493 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.789 |
| murI | ispE | Apre_0492 | Apre_0491 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.804 |
| murI | ppk | Apre_0492 | Apre_0494 | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.789 |
| polA | Apre_0493 | Apre_1330 | Apre_0493 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | PFAM: Ppx/GppA phosphatase; KEGG: bcb:BCB4264_A4099 Ppx/GppA phosphatase family protein. | 0.437 |
| polA | ppk | Apre_1330 | Apre_0494 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.560 |