Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
Apre_0535Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (443 aa)    
Predicted Functional Partners:
Apre_0538
PFAM: Chromosomal replication initiator DnaA; SMART: AAA ATPase; KEGG: bcr:BCAH187_A4023 putative prophage LambdaBa02, DNA replication protein DnaC.
  
 
 0.962
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 0.952
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 
 0.893
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.865
Apre_0537
TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region.
  
  
 0.847
Apre_0809
SMART: AAA ATPase; KEGG: bar:GBAA0439 hypothetical protein.
  
 
 0.826
Apre_0533
Phosphoesterase RecJ domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family.
  
  
 0.821
Apre_0536
PFAM: GCN5-related N-acetyltransferase; KEGG: bcr:BCAH187_A4903 acetyltransferase, GNAT family.
  
    0.812
nnrE
Carbohydrate kinase, YjeF related protein; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.
       0.808
Apre_0532
KEGG: sat:SYN_00642 hypothetical protein.
       0.781
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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