| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0433 | Apre_0946 | Apre_0433 | Apre_0946 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: bha:BH1334 late competence operon required for DNA binding and uptake. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.943 |
| Apre_0433 | tdk | Apre_0433 | Apre_1047 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: bha:BH1334 late competence operon required for DNA binding and uptake. | PFAM: thymidine kinase; KEGG: hypothetical protein. | 0.932 |
| Apre_0433 | thyX | Apre_0433 | Apre_0772 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: bha:BH1334 late competence operon required for DNA binding and uptake. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.908 |
| Apre_0433 | tmk | Apre_0433 | Apre_1128 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: bha:BH1334 late competence operon required for DNA binding and uptake. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.928 |
| Apre_0946 | Apre_0433 | Apre_0946 | Apre_0433 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: bha:BH1334 late competence operon required for DNA binding and uptake. | 0.943 |
| Apre_0946 | purN | Apre_0946 | Apre_1109 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.419 |
| Apre_0946 | tdk | Apre_0946 | Apre_1047 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | PFAM: thymidine kinase; KEGG: hypothetical protein. | 0.972 |
| Apre_0946 | thyX | Apre_0946 | Apre_0772 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.930 |
| Apre_0946 | tmk | Apre_0946 | Apre_1128 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.939 |
| Apre_1131 | fmt | Apre_1131 | Apre_0663 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.975 |
| Apre_1131 | glyA | Apre_1131 | Apre_0915 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
| Apre_1131 | purH | Apre_1131 | Apre_1108 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | KEGG: bcy:Bcer98_0277 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.975 |
| Apre_1131 | purN | Apre_1131 | Apre_1109 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
| Apre_1131 | thyX | Apre_1131 | Apre_0772 | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.917 |
| Apre_1626 | fmt | Apre_1626 | Apre_0663 | PFAM: dihydrofolate reductase region; KEGG: fta:FTA_0239 dihydrofolate reductase type I. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.932 |
| Apre_1626 | glyA | Apre_1626 | Apre_0915 | PFAM: dihydrofolate reductase region; KEGG: fta:FTA_0239 dihydrofolate reductase type I. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
| Apre_1626 | purH | Apre_1626 | Apre_1108 | PFAM: dihydrofolate reductase region; KEGG: fta:FTA_0239 dihydrofolate reductase type I. | KEGG: bcy:Bcer98_0277 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. | 0.924 |
| Apre_1626 | purN | Apre_1626 | Apre_1109 | PFAM: dihydrofolate reductase region; KEGG: fta:FTA_0239 dihydrofolate reductase type I. | Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
| Apre_1626 | thyX | Apre_1626 | Apre_0772 | PFAM: dihydrofolate reductase region; KEGG: fta:FTA_0239 dihydrofolate reductase type I. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.930 |
| fmt | Apre_1131 | Apre_0663 | Apre_1131 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: bha:BH2784 methylenetetrahydrofolate dehydrogenase. | 0.975 |
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