| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0262 | Apre_0782 | Apre_0262 | Apre_0782 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.847 |
| Apre_0262 | Apre_0784 | Apre_0262 | Apre_0784 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative. | 0.755 |
| Apre_0262 | pyrB | Apre_0262 | Apre_0780 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | KEGG: vfm:VFMJ11_0396 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.870 |
| Apre_0262 | pyrD | Apre_0262 | Apre_0785 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.832 |
| Apre_0262 | pyrE | Apre_0262 | Apre_0786 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.845 |
| Apre_0262 | pyrF | Apre_0262 | Apre_0783 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: hne:HNE_0128 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.723 |
| Apre_0550 | Apre_0784 | Apre_0550 | Apre_0784 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative. | 0.822 |
| Apre_0550 | pyrD | Apre_0550 | Apre_0785 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sat:SYN_00606 glutamate synthase (NADPH). | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.501 |
| Apre_0781 | Apre_0782 | Apre_0781 | Apre_0782 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.982 |
| Apre_0781 | Apre_0784 | Apre_0781 | Apre_0784 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative. | 0.847 |
| Apre_0781 | pyrB | Apre_0781 | Apre_0780 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | KEGG: vfm:VFMJ11_0396 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| Apre_0781 | pyrD | Apre_0781 | Apre_0785 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.903 |
| Apre_0781 | pyrE | Apre_0781 | Apre_0786 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.796 |
| Apre_0781 | pyrF | Apre_0781 | Apre_0783 | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: hne:HNE_0128 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.956 |
| Apre_0782 | Apre_0262 | Apre_0782 | Apre_0262 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ypb:YPTS_2898 uracil-xanthine permease. | 0.847 |
| Apre_0782 | Apre_0781 | Apre_0782 | Apre_0781 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PFAM: aspartate transcarbamylase regulatory subunit; KEGG: vpa:VP2655 aspartate carbamoyltransferase regulatory subunit. | 0.982 |
| Apre_0782 | Apre_0784 | Apre_0782 | Apre_0784 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: gsu:GSU1756 dihydroorotate dehydrogenase, electron transfer subunit, putative. | 0.997 |
| Apre_0782 | pyrB | Apre_0782 | Apre_0780 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | KEGG: vfm:VFMJ11_0396 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| Apre_0782 | pyrD | Apre_0782 | Apre_0785 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.998 |
| Apre_0782 | pyrE | Apre_0782 | Apre_0786 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.966 |