STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (387 aa)    
Predicted Functional Partners:
Apre_0924
PFAM: aminotransferase class V; KEGG: bcy:Bcer98_3320 aminotransferase class V.
 
 0.994
Apre_0565
PFAM: aminotransferase class V; KEGG: bsu:BSU27510 hypothetical protein.
 
 0.970
Apre_1633
TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: thiF; ThiS adenylation protein ThiF.
    
 0.928
Apre_1632
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
     
 0.924
Apre_0664
Fmu (Sun) domain protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
   
    0.837
Apre_0927
PFAM: protein of unknown function DUF464; KEGG: bcr:BCAH187_A4576 hypothetical protein.
  
    0.619
Apre_0923
KEGG: sat:SYN_00384 hypothetical protein.
       0.600
rplU
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
    0.594
Apre_0932
KEGG: bha:BH1327 hypothetical protein; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region.
 
     0.584
rpmA
TIGRFAM: ribosomal protein L27; PFAM: ribosomal protein L27; KEGG: bsu:BSU27940 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.
       0.573
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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