STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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Experiments
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[Homology]
Score
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa)    
Predicted Functional Partners:
purC
PFAM: SAICAR synthetase; KEGG: sat:SYN_00107 phosphoribosylaminoimidazole- succinocarboxamide synthase.
 
 
 0.998
purD
KEGG: dno:DNO_1110 phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; phosphoribosylamine/glycine ligase; PFAM: AIR synthase related protein domain protein; phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Belongs to the GARS family.
  
 0.998
purM
Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: bcy:Bcer98_0275 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
 
  
 0.992
purH
KEGG: bcy:Bcer98_0277 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region.
 
  
 0.991
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
  
 0.991
purN
Formyl transferase domain protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
  
 0.990
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.920
fhs
PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: bcy:Bcer98_1593 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
  
 0.786
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
   
 0.601
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
  
 0.584
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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