| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Apre_0357 | Apre_1425 | Apre_0357 | Apre_1425 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | 0.596 |
| Apre_0357 | Apre_1430 | Apre_0357 | Apre_1430 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | 0.901 |
| Apre_0357 | purD | Apre_0357 | Apre_1107 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | KEGG: dno:DNO_1110 phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; phosphoribosylamine/glycine ligase; PFAM: AIR synthase related protein domain protein; phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Belongs to the GARS family. | 0.524 |
| Apre_0357 | pyrB | Apre_0357 | Apre_0780 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | KEGG: vfm:VFMJ11_0396 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.953 |
| Apre_0357 | pyrD | Apre_0357 | Apre_0785 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.780 |
| Apre_0357 | pyrE | Apre_0357 | Apre_0786 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.721 |
| Apre_0357 | pyrF | Apre_0357 | Apre_0783 | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: hne:HNE_0128 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.721 |
| Apre_0782 | Apre_1425 | Apre_0782 | Apre_1425 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | 0.592 |
| Apre_0782 | purD | Apre_0782 | Apre_1107 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | KEGG: dno:DNO_1110 phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; phosphoribosylamine/glycine ligase; PFAM: AIR synthase related protein domain protein; phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Belongs to the GARS family. | 0.524 |
| Apre_0782 | pyrB | Apre_0782 | Apre_0780 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | KEGG: vfm:VFMJ11_0396 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| Apre_0782 | pyrD | Apre_0782 | Apre_0785 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. | 0.998 |
| Apre_0782 | pyrE | Apre_0782 | Apre_0786 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.966 |
| Apre_0782 | pyrF | Apre_0782 | Apre_0783 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: hne:HNE_0128 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.952 |
| Apre_1424 | Apre_1425 | Apre_1424 | Apre_1425 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: ecc:c3444 xanthine dehydrogenase subunit XdhA. | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | 0.621 |
| Apre_1424 | xpt | Apre_1424 | Apre_0380 | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: ecc:c3444 xanthine dehydrogenase subunit XdhA. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.907 |
| Apre_1425 | Apre_0357 | Apre_1425 | Apre_0357 | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | 0.596 |
| Apre_1425 | Apre_0782 | Apre_1425 | Apre_0782 | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.592 |
| Apre_1425 | Apre_1424 | Apre_1425 | Apre_1424 | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: ecc:c3444 xanthine dehydrogenase subunit XdhA. | 0.621 |
| Apre_1425 | Apre_1430 | Apre_1425 | Apre_1430 | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | Dihydropyrimidinase; KEGG: ppr:PBPRA1991 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3. | 0.698 |
| Apre_1425 | purD | Apre_1425 | Apre_1107 | TIGRFAM: xanthine permease; uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: dps:DP1412 xanthine permease. | KEGG: dno:DNO_1110 phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; phosphoribosylamine/glycine ligase; PFAM: AIR synthase related protein domain protein; phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Belongs to the GARS family. | 0.832 |