STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobBSilent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (246 aa)    
Predicted Functional Partners:
Apre_0507
TIGRFAM: NAD+ synthetase; PFAM: NAD synthase; Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: pca:Pcar_2216 NAD synthetase.
   
 0.946
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.930
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.923
deoD
TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: cps:CPS_1978 purine nucleoside phosphorylase.
    
 0.922
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.843
Apre_1481
Hypothetical protein; KEGG: bar:GBAA1373 GntR family transcriptional regulator.
  
    0.829
Apre_0188
PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: nme:NMB1476 glutamate dehydrogenase, NAD- specific; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.821
Apre_1477
TIGRFAM: MJ0042 family finger-like protein.
       0.796
Apre_1479
Hypothetical protein; KEGG: bba:Bd0861 pilus biogenesis protein and ABC- type transporter.
  
   0.794
Apre_1480
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: bcy:Bcer98_1078 ABC transporter-related protein.
  
   0.794
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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