STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa)    
Predicted Functional Partners:
pgi
PFAM: phosphoglucose isomerase (PGI); KEGG: bha:BH3343 glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.977
Apre_0677
TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: bha:BH3163 pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.942
Apre_0749
Fructose-1,6-bisphosphate aldolase, class II; KEGG: bcy:Bcer98_3856 fructose-bisphosphate aldolase; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II.
 
 
 0.941
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
0.927
Apre_1616
TIGRFAM: transketolase; PFAM: Transketolase central region; Transketolase domain protein; KEGG: bcb:BCB4264_A3790 transketolase; Belongs to the transketolase family.
  
 
 0.921
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.918
Apre_0069
PFAM: Ribose/galactose isomerase; KEGG: mxa:MXAN_4767 ribose 5-phosphate isomerase B.
  
 
 0.915
Apre_0070
Sugar-phosphate isomerase, RpiB/LacA/LacB family; KEGG: ribose 5-phosphate isomerase B family protein; K01808 ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase.
  
 
 0.915
fbp
PFAM: fructose-16-bisphosphatase; KEGG: bsu:BSU40190 fructose-1,6-bisphosphatase.
     
 0.913
Apre_0141
KEGG: bcy:Bcer98_1171 mannose-6-phosphate isomerase, class I; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I.
    
 0.912
Your Current Organism:
Anaerococcus prevotii DSM 20548
NCBI taxonomy Id: 525919
Other names: A. prevotii DSM 20548, Anaerococcus prevotii ATCC 9321, Anaerococcus prevotii CCUG 41932, Anaerococcus prevotii str. DSM 20548, Anaerococcus prevotii strain DSM 20548
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