SIQ08601.1 protein (Acidiphilium rubrum) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SIQ08601.1

Chitinase class I. (207 aa)

Predicted Functional Partners:

tal

0.907

SIQ08630.1

0.773

SIQ15292.1

0.684

SIR39023.1

0.681

SIQ59016.1

0.612

SIQ15056.1

0.579

SIQ53645.1

0.579

SIR38043.1

0.579

SIQ08572.1

0.550

SIQ81531.1

0.484

Your Current Organism:

Acidiphilium rubrum

NCBI taxonomy Id: 526
Other names: A. rubrum, ATCC 35905, Acidiphilum rubrum, strain OP

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIQ08572.1	SIQ08601.1	SAMN05421828_101212	SAMN05421828_101213	Hypothetical protein.	Chitinase class I.	0.550
SIQ08572.1	SIQ08630.1	SAMN05421828_101212	SAMN05421828_101214	Hypothetical protein.	Hypothetical protein.	0.550
SIQ08601.1	SIQ08572.1	SAMN05421828_101213	SAMN05421828_101212	Chitinase class I.	Hypothetical protein.	0.550
SIQ08601.1	SIQ08630.1	SAMN05421828_101213	SAMN05421828_101214	Chitinase class I.	Hypothetical protein.	0.773
SIQ08601.1	SIQ15056.1	SAMN05421828_101213	SAMN05421828_10221	Chitinase class I.	Cell division protein FtsI (penicillin-binding protein 3).	0.579
SIQ08601.1	SIQ15292.1	SAMN05421828_101213	SAMN05421828_10229	Chitinase class I.	N-acetylmuramoyl-L-alanine amidase.	0.684
SIQ08601.1	SIQ53645.1	SAMN05421828_101213	SAMN05421828_10617	Chitinase class I.	Peptidoglycan glycosyltransferase.	0.579
SIQ08601.1	SIQ59016.1	SAMN05421828_101213	SAMN05421828_106169	Chitinase class I.	beta-N-acetylhexosaminidase.	0.612
SIQ08601.1	SIQ81531.1	SAMN05421828_101213	SAMN05421828_1105	Chitinase class I.	D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.	0.484
SIQ08601.1	SIR38043.1	SAMN05421828_101213	SAMN05421828_12736	Chitinase class I.	Cell division protein FtsI (penicillin-binding protein 3).	0.579
SIQ08601.1	SIR39023.1	SAMN05421828_101213	SAMN05421828_12812	Chitinase class I.	N-acetylmuramoyl-L-alanine amidase.	0.681
SIQ08601.1	tal	SAMN05421828_101213	SAMN05421828_11716	Chitinase class I.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family.	0.907
SIQ08630.1	SIQ08572.1	SAMN05421828_101214	SAMN05421828_101212	Hypothetical protein.	Hypothetical protein.	0.550
SIQ08630.1	SIQ08601.1	SAMN05421828_101214	SAMN05421828_101213	Hypothetical protein.	Chitinase class I.	0.773
SIQ15056.1	SIQ08601.1	SAMN05421828_10221	SAMN05421828_101213	Cell division protein FtsI (penicillin-binding protein 3).	Chitinase class I.	0.579
SIQ15056.1	SIQ53645.1	SAMN05421828_10221	SAMN05421828_10617	Cell division protein FtsI (penicillin-binding protein 3).	Peptidoglycan glycosyltransferase.	0.670
SIQ15056.1	SIQ81531.1	SAMN05421828_10221	SAMN05421828_1105	Cell division protein FtsI (penicillin-binding protein 3).	D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.	0.717
SIQ15056.1	SIR38043.1	SAMN05421828_10221	SAMN05421828_12736	Cell division protein FtsI (penicillin-binding protein 3).	Cell division protein FtsI (penicillin-binding protein 3).	0.613
SIQ15292.1	SIQ08601.1	SAMN05421828_10229	SAMN05421828_101213	N-acetylmuramoyl-L-alanine amidase.	Chitinase class I.	0.684
SIQ15292.1	SIQ59016.1	SAMN05421828_10229	SAMN05421828_106169	N-acetylmuramoyl-L-alanine amidase.	beta-N-acetylhexosaminidase.	0.847

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.787

expected number of edges:

10

PPI enrichment p-value:

0.0391

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

10 of 249

0.85

0.84

1.28e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042626

ATPase-coupled transmembrane transporter activity

5 of 57

1.19

1.12

0.00033

GO:0140359

ABC-type transporter activity

4 of 39

1.26

1.04

0.0016

GO:0005524

ATP binding

10 of 261

0.83

0.82

1.05e-05

GO:0022857

Transmembrane transporter activity

8 of 210

0.83

0.76

9.66e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

10 of 571

0.49

0.38

0.0041

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2923

Transcription regulators MarR/SlyA-like, and ABC transporter transmembrane region

4 of 5

2.15

2.51

9.61e-06

CL:2919

Mixed, incl. ABC transporter transmembrane region, and ABC transporter, CbiO/EcfA subunit

5 of 31

1.46

1.59

5.78e-05

CL:2914

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

9 of 108

1.17

1.51

1.53e-07

CL:2915

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

8 of 93

1.18

1.45

1.18e-06

CL:2916

Mixed, incl. Latent infection - Other responses of Mtb to phagocytosis, and ABC transporters

7 of 82

1.18

1.34

9.66e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

adc02010

ABC transporters

6 of 90

1.07

0.97

0.00042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

2 of 15

1.37

0.62

0.0483

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

7 of 236

0.72

0.49

0.0111

GOCC:0016020

Membrane

8 of 319

0.65

0.45

0.0111

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1278

Translocase

3 of 10

1.73

1.29

0.0020

KW-0067

ATP-binding

10 of 211

0.92

1.02

4.39e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017871

ABC transporter-like, conserved site

10 of 60

1.47

2.74

1.49e-11

IPR003439

ABC transporter-like, ATP-binding domain

10 of 67

1.42

2.57

2.05e-11

IPR003593

AAA+ ATPase domain

10 of 84

1.32

2.18

1.12e-10

IPR027417

P-loop containing nucleoside triphosphate hydrolase

10 of 157

1.05

1.32

3.16e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

10 of 81

1.34

2.29

2.19e-11

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