STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (181 aa)    
Predicted Functional Partners:
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.967
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.950
ACZ09790.1
PFAM: protein of unknown function DUF370; KEGG: sfu:Sfum_3631 hypothetical protein; Belongs to the RemA family.
  
    0.944
ACZ08054.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.936
ACZ09788.1
Hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.934
ACZ09004.1
TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: ADL; adenylosuccinate lyase; K01756 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 
 0.932
ACZ08901.1
KEGG: spe:Spro_3998 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.927
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.925
ACZ09002.1
KEGG: vfm:VFMJ11_2290 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.917
ACZ09609.1
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
   
 
 0.914
Your Current Organism:
Sebaldella termitidis
NCBI taxonomy Id: 526218
Other names: S. termitidis ATCC 33386, Sebaldella termitidis ATCC 33386, Sebaldella termitidis NCTC 11300, Sebaldella termitidis str. ATCC 33386, Sebaldella termitidis strain ATCC 33386
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