node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VDBG_00140 | VDBG_00356 | C9S8V6 | C9S5M3 | 3'-5' exonuclease domain-containing protein. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.999 |
VDBG_00140 | VDBG_00651 | C9S8V6 | C9S6Q2 | 3'-5' exonuclease domain-containing protein. | DNA repair and recombination protein rad22. | 0.997 |
VDBG_00140 | VDBG_00972 | C9S8V6 | C9S7X8 | 3'-5' exonuclease domain-containing protein. | Uncharacterized protein. | 0.994 |
VDBG_00140 | VDBG_03253 | C9S8V6 | C9SDM4 | 3'-5' exonuclease domain-containing protein. | Exodeoxyribonuclease. | 0.997 |
VDBG_00140 | VDBG_04420 | C9S8V6 | C9SJE9 | 3'-5' exonuclease domain-containing protein. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.998 |
VDBG_00140 | VDBG_05514 | C9S8V6 | C9SL37 | 3'-5' exonuclease domain-containing protein. | DNA repair protein RAD57. | 0.994 |
VDBG_00140 | VDBG_05694 | C9S8V6 | C9SLL7 | 3'-5' exonuclease domain-containing protein. | Double-strand break repair protein mus-23; Belongs to the MRE11/RAD32 family. | 0.996 |
VDBG_00140 | VDBG_06033 | C9S8V6 | C9SMA9 | 3'-5' exonuclease domain-containing protein. | Crossover junction endonuclease MUS81. | 0.991 |
VDBG_00140 | VDBG_06833 | C9S8V6 | C9SPK8 | 3'-5' exonuclease domain-containing protein. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.989 |
VDBG_00140 | VDBG_08063 | C9S8V6 | C9ST38 | 3'-5' exonuclease domain-containing protein. | ATP-dependent DNA helicase srs2. | 0.852 |
VDBG_00356 | VDBG_00140 | C9S5M3 | C9S8V6 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 3'-5' exonuclease domain-containing protein. | 0.999 |
VDBG_00356 | VDBG_00651 | C9S5M3 | C9S6Q2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair and recombination protein rad22. | 0.997 |
VDBG_00356 | VDBG_00972 | C9S5M3 | C9S7X8 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.898 |
VDBG_00356 | VDBG_03253 | C9S5M3 | C9SDM4 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Exodeoxyribonuclease. | 0.868 |
VDBG_00356 | VDBG_04420 | C9S5M3 | C9SJE9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.986 |
VDBG_00356 | VDBG_05514 | C9S5M3 | C9SL37 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair protein RAD57. | 0.877 |
VDBG_00356 | VDBG_05694 | C9S5M3 | C9SLL7 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Double-strand break repair protein mus-23; Belongs to the MRE11/RAD32 family. | 0.947 |
VDBG_00356 | VDBG_06033 | C9S5M3 | C9SMA9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Crossover junction endonuclease MUS81. | 0.855 |
VDBG_00356 | VDBG_06833 | C9S5M3 | C9SPK8 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.873 |
VDBG_00356 | VDBG_08063 | C9S5M3 | C9ST38 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | ATP-dependent DNA helicase srs2. | 0.531 |