node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VDBG_00356 | VDBG_01666 | C9S5M3 | C9SAY3 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | 0.978 |
VDBG_00356 | VDBG_03253 | C9S5M3 | C9SDM4 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Exodeoxyribonuclease. | 0.868 |
VDBG_00356 | VDBG_03648 | C9S5M3 | C9SGP4 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | RMI1_N domain-containing protein. | 0.909 |
VDBG_00356 | VDBG_04420 | C9S5M3 | C9SJE9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.986 |
VDBG_00356 | VDBG_05582 | C9S5M3 | C9SLA5 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.855 |
VDBG_00356 | VDBG_05694 | C9S5M3 | C9SLL7 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Double-strand break repair protein mus-23; Belongs to the MRE11/RAD32 family. | 0.947 |
VDBG_00356 | VDBG_06033 | C9S5M3 | C9SMA9 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Crossover junction endonuclease MUS81. | 0.855 |
VDBG_00356 | VDBG_06833 | C9S5M3 | C9SPK8 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.873 |
VDBG_00356 | VDBG_08137 | C9S5M3 | C9STB2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA replication ATP-dependent helicase dna2. | 0.985 |
VDBG_00356 | VDBG_08857 | C9S5M3 | C9SVD2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.985 |
VDBG_01666 | VDBG_00356 | C9SAY3 | C9S5M3 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.978 |
VDBG_01666 | VDBG_03253 | C9SAY3 | C9SDM4 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | Exodeoxyribonuclease. | 0.917 |
VDBG_01666 | VDBG_03648 | C9SAY3 | C9SGP4 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | RMI1_N domain-containing protein. | 0.734 |
VDBG_01666 | VDBG_04420 | C9SAY3 | C9SJE9 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.820 |
VDBG_01666 | VDBG_05582 | C9SAY3 | C9SLA5 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.821 |
VDBG_01666 | VDBG_05694 | C9SAY3 | C9SLL7 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | Double-strand break repair protein mus-23; Belongs to the MRE11/RAD32 family. | 0.974 |
VDBG_01666 | VDBG_06033 | C9SAY3 | C9SMA9 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | Crossover junction endonuclease MUS81. | 0.726 |
VDBG_01666 | VDBG_06833 | C9SAY3 | C9SPK8 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.998 |
VDBG_01666 | VDBG_08137 | C9SAY3 | C9STB2 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | DNA replication ATP-dependent helicase dna2. | 0.856 |
VDBG_01666 | VDBG_08857 | C9SAY3 | C9SVD2 | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.748 |