STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VDBG_06833Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2923 aa)    
Predicted Functional Partners:
VDBG_01666
Protein kinase rad3; Belongs to the PI3/PI4-kinase family.
   
0.998
VDBG_05694
Double-strand break repair protein mus-23; Belongs to the MRE11/RAD32 family.
   
 0.991
VDBG_00140
3'-5' exonuclease domain-containing protein.
   
 0.989
VDBG_07227
DNA repair protein RAD50.
   
 0.986
VDBG_06588
BRCT domain-containing protein.
    
 0.973
VDBG_05536
DNA damage-responsive transcriptional repressor RPH1.
    
 0.967
VDBG_06132
Peroxisomal targeting signal receptor.
    
 0.960
VDBG_08268
Ku70.
    
 0.927
VDBG_04420
DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.
    
 0.925
VDBG_05916
Cell cycle checkpoint protein RAD17.
   
 0.925
Your Current Organism:
Verticillium alfalfae
NCBI taxonomy Id: 526221
Other names: V. alfalfae VaMs.102, Verticillium alfalfae VaMs.102
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