STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queHProtein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (184 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
  
 0.828
rnhB
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
 
      0.816
ACS78231.1
Ribonuclease, Rne/Rng family; KEGG: dde:Dde_0537 ribonuclease E; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein; SMART: RNA binding S1 domain protein.
       0.661
ACS78230.1
PFAM: Radical SAM domain protein; KEGG: dde:Dde_0538 radical SAM domain-containing protein.
       0.558
ACS78233.1
PFAM: UspA domain protein; KEGG: dde:Dde_2827 hypothetical protein.
       0.520
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
 
   
 0.492
ACS78234.1
Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
       0.485
ACS81707.1
PFAM: homocysteine S-methyltransferase; cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; dihydropteroate synthase DHPS; KEGG: dde:Dde_2115 methionine synthase (B12-dependent).
      
 0.420
Your Current Organism:
Desulfovibrio salexigens
NCBI taxonomy Id: 526222
Other names: D. salexigens DSM 2638, Desulfovibrio salexigens ATCC 14822, Desulfovibrio salexigens DSM 2638, Desulfovibrio salexigens str. DSM 2638, Desulfovibrio salexigens strain DSM 2638
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.