node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmur_2183 | fhs | Bmur_2183 | Bmur_2125 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.979 |
Bmur_2183 | folD | Bmur_2183 | Bmur_1444 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.859 |
Bmur_2183 | glyA | Bmur_2183 | Bmur_2311 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |
Bmur_2183 | purC | Bmur_2183 | Bmur_0712 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; KEGG: bhy:BHWA1_01150 phosphoribosylamidoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.999 |
Bmur_2183 | purD | Bmur_2183 | Bmur_1913 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: bhy:BHWA1_01297 phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.999 |
Bmur_2183 | purE | Bmur_2183 | Bmur_0713 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
Bmur_2183 | purF | Bmur_2183 | Bmur_0228 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
Bmur_2183 | purH | Bmur_2183 | Bmur_2167 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: bhy:BHWA1_02509 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. | 0.999 |
Bmur_2183 | purM | Bmur_2183 | Bmur_1033 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; KEGG: bhy:BHWA1_01445 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | 0.999 |
Bmur_2183 | purN | Bmur_2183 | Bmur_1032 | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
fhs | Bmur_2183 | Bmur_2125 | Bmur_2183 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: bhy:BHWA1_02433 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein. | 0.979 |
fhs | folD | Bmur_2125 | Bmur_1444 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | Bmur_2125 | Bmur_2311 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
fhs | purC | Bmur_2125 | Bmur_0712 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; KEGG: bhy:BHWA1_01150 phosphoribosylamidoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.847 |
fhs | purD | Bmur_2125 | Bmur_1913 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: bhy:BHWA1_01297 phosphoribosylamine-glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP- grasp (A) domain; Phosphoribosylglycinamide synthetase, N- domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. | 0.611 |
fhs | purE | Bmur_2125 | Bmur_0713 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.609 |
fhs | purF | Bmur_2125 | Bmur_0228 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.778 |
fhs | purH | Bmur_2125 | Bmur_2167 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: bhy:BHWA1_02509 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. | 0.985 |
fhs | purM | Bmur_2125 | Bmur_1033 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; KEGG: bhy:BHWA1_01445 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. | 0.457 |
fhs | purN | Bmur_2125 | Bmur_1032 | KEGG: bhy:BHWA1_02387 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.959 |