Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (450 aa)    
Predicted Functional Partners:
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: bhy:BHWA1_00122 phenylalanyl-tRNA synthetase alpha chain.
 
  
 0.749
Bmur_1817
SMART: beta-lactamase domain protein; KEGG: bhy:BHWA1_01360 beta-lactamase domain protein.
  
  
 0.742
Bmur_1816
PFAM: Domain of unknown function DUF1848; KEGG: bhy:BHWA1_01361 hypothetical protein.
       0.740
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
  
 0.721
Bmur_1818
KEGG: bhy:BHWA1_01359 hypothetical protein.
  
  
 0.714
Bmur_1543
TIGRFAM: hypoxanthine phosphoribosyltransferase; KEGG: bhy:BHWA1_01908 hypoxanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.692
Bmur_1660
TIGRFAM: protein-(glutamine-N5) methyltransferase, release factor-specific; modification methylase, HemK family; KEGG: bhy:BHWA1_02097 modification methylase, HemK family.
 
  
 0.644
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
  
 0.636
Bmur_0771
KEGG: bhy:BHWA1_02497 peptidyl-tRNA hydrolase; PFAM: peptidyl-tRNA hydrolase.
  
  
 0.597
Bmur_2589
KEGG: bhy:BHWA1_01804 ComFC, predicted amidophosphoribosyltransferase.
  
  
 0.597
Your Current Organism:
Brachyspira murdochii
NCBI taxonomy Id: 526224
Other names: B. murdochii DSM 12563, Brachyspira murdochii 56-150, Brachyspira murdochii ATCC 51284, Brachyspira murdochii CIP 105832, Brachyspira murdochii DSM 12563, Brachyspira murdochii str. DSM 12563, Brachyspira murdochii strain DSM 12563
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