STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Bmur_2421N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; KEGG: bhy:BHWA1_02589 N-acetylmuramoyl-L-alanine amidase; SMART: cell wall hydrolase/autolysin. (309 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.823
Bmur_2419
KEGG: bhy:BHWA1_02591 putative DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein.
       0.655
Bmur_2418
KEGG: bhy:BHWA1_02592 TPR domain-containing protein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SMART: Tetratricopeptide repeat.
       0.645
Bmur_2422
KEGG: gwc:GWCH70_3230 hypothetical protein.
       0.603
Bmur_2423
KEGG: gwc:GWCH70_3229 hypothetical protein.
       0.603
Bmur_0189
Penicillin-binding protein, 1A family; KEGG: bhy:BHWA1_00340 membrane carboxypeptidase; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin- binding protein transpeptidase.
 
   
 0.544
Bmur_0536
PFAM: MotA/TolQ/ExbB proton channel; KEGG: bhy:BHWA1_00538 biopolymer transport protein ExbB.
  
  
 0.541
Bmur_0106
PFAM: permease YjgP/YjgQ family protein; KEGG: bhy:BHWA1_00472 permease.
  
     0.536
Bmur_1808
KEGG: bhy:BHWA1_01372 outer membrane protein; TIGRFAM: outer membrane protein assembly complex, YaeT protein; PFAM: surface antigen (D15); surface antigen variable number repeat protein.
 
   
 0.532
Bmur_0309
PFAM: permease YjgP/YjgQ family protein; KEGG: bhy:BHWA1_00769 permease YjgP/YjgQ.
  
     0.522
Your Current Organism:
Brachyspira murdochii
NCBI taxonomy Id: 526224
Other names: B. murdochii DSM 12563, Brachyspira murdochii 56-150, Brachyspira murdochii ATCC 51284, Brachyspira murdochii CIP 105832, Brachyspira murdochii DSM 12563, Brachyspira murdochii str. DSM 12563, Brachyspira murdochii strain DSM 12563
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