STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Bmur_2589KEGG: bhy:BHWA1_01804 ComFC, predicted amidophosphoribosyltransferase. (175 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.997
Bmur_0509
PFAM: metallophosphoesterase; KEGG: bhy:BHWA1_00716 putative exonuclease.
 
 0.993
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.977
Bmur_0898
KEGG: bhy:BHWA1_01286 TPR domain-containing protein; PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat.
 
 
 0.968
Bmur_2054
PFAM: TPR repeat-containing protein; KEGG: bhy:BHWA1_01643 TPR domain-containing protein.
  
 
 0.950
Bmur_0731
SNF2-related protein; KEGG: bhy:BHWA1_00700 HepA, superfamily II D/R helicase, SNF2 family; PFAM: SNF2-related protein; helicase domain protein; SNF2 helicase associated domain protein; SMART: DEAD-like helicase; helicase domain protein.
  
 
 0.902
Bmur_0937
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.890
Bmur_0024
SMART: helicase c2; DEAD-like helicase; KEGG: bhy:BHWA1_00600 helicase.
  
 0.814
Bmur_1261
KEGG: bhy:BHWA1_01595 TPR domain-containing protein; PFAM: Tetratricopeptide TPR_2 repeat protein; Sel1 domain protein repeat-containing protein; SMART: Sel1 domain protein repeat-containing protein; Tetratricopeptide repeat.
 
   0.788
Your Current Organism:
Brachyspira murdochii
NCBI taxonomy Id: 526224
Other names: B. murdochii DSM 12563, Brachyspira murdochii 56-150, Brachyspira murdochii ATCC 51284, Brachyspira murdochii CIP 105832, Brachyspira murdochii DSM 12563, Brachyspira murdochii str. DSM 12563, Brachyspira murdochii strain DSM 12563
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.