| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Gobs_0002 | Gobs_0747 | Gobs_0002 | Gobs_0747 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | 0.665 |
| Gobs_0002 | Gobs_2694 | Gobs_0002 | Gobs_2694 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: kra:Krad_1887 5'-3' exonuclease. | 0.918 |
| Gobs_0002 | Gobs_4232 | Gobs_0002 | Gobs_4232 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; KEGG: art:Arth_2753 UvrD/REP helicase. | 0.969 |
| Gobs_0002 | Gobs_4360 | Gobs_0002 | Gobs_4360 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: sen:SACE_0953 putative ATP-dependent dsDNA exonuclease. | 0.420 |
| Gobs_0002 | Gobs_4430 | Gobs_0002 | Gobs_4430 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: sco:SCO4797 ATP-dependent DNA helicase II. | 0.836 |
| Gobs_0002 | polA | Gobs_0002 | Gobs_3201 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.986 |
| Gobs_0002 | recA | Gobs_0002 | Gobs_3919 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.939 |
| Gobs_0002 | sbcD | Gobs_0002 | Gobs_4361 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.462 |
| Gobs_0002 | topA | Gobs_0002 | Gobs_0605 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.752 |
| Gobs_0747 | Gobs_0002 | Gobs_0747 | Gobs_0002 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.665 |
| Gobs_0747 | Gobs_2694 | Gobs_0747 | Gobs_2694 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: kra:Krad_1887 5'-3' exonuclease. | 0.433 |
| Gobs_0747 | Gobs_4232 | Gobs_0747 | Gobs_4232 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein; KEGG: art:Arth_2753 UvrD/REP helicase. | 0.955 |
| Gobs_0747 | Gobs_4243 | Gobs_0747 | Gobs_4243 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | PFAM: UvrD/REP helicase; KEGG: saq:Sare_4130 UvrD/REP helicase. | 0.650 |
| Gobs_0747 | Gobs_4360 | Gobs_0747 | Gobs_4360 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | KEGG: sen:SACE_0953 putative ATP-dependent dsDNA exonuclease. | 0.552 |
| Gobs_0747 | Gobs_4430 | Gobs_0747 | Gobs_4430 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase; KEGG: sco:SCO4797 ATP-dependent DNA helicase II. | 0.483 |
| Gobs_0747 | polA | Gobs_0747 | Gobs_3201 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.852 |
| Gobs_0747 | recA | Gobs_0747 | Gobs_3919 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.546 |
| Gobs_0747 | sbcD | Gobs_0747 | Gobs_4361 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.560 |
| Gobs_0747 | topA | Gobs_0747 | Gobs_0605 | PFAM: TrwC relaxase; DNA primase catalytic core domain; TOPRIM domain protein; SMART: Toprim sub domain protein; KEGG: nca:Noca_4800 DNA primase catalytic core. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.737 |
| Gobs_2694 | Gobs_0002 | Gobs_2694 | Gobs_0002 | PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: kra:Krad_1887 5'-3' exonuclease. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.918 |
