STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADH63329.1KEGG: ttj:TTHA1455 succinate dehydrogenase, membrane subunit (SdhD); SPTR: C1XVW5 Succinate dehydrogenase subunit D; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (130 aa)    
Predicted Functional Partners:
ADH63328.1
InterPro IPR014314:IPR000701; KEGG: ttj:TTHA1456 succinate dehydrogenase, cytochrome subunit; PFAM: succinate dehydrogenase cytochrome b subunit; SPTR: C1XVW6 Succinate dehydrogenase subunit C; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit.
 
 0.999
ADH63330.1
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterProIPR003952:IPR004112:IPR013027:IPR003953:IPR 014006:IPR015939:IPR011281; KEGG: ttj:TTHA1454 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: C1XVW4 Succinate dehydrogenase subunit A; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; succinate dehydrogenase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgr [...]
 
 0.999
ADH63331.1
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterProIPR001041:IPR017896:IPR012675:IPR012285:IPR 009051:IPR017900:IPR004489; KEGG: tth:TTC1089 succinate dehydrogenase iron-sulfur subunit; PRIAM: Succinate dehydrogenase; SPTR: C1XVW3 Succinate dehydrogenase subunit B; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
 
 0.999
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.985
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.943
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 
 0.920
ADH64059.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016161:IPR015590:IPR016162; KEGG: ddr:Deide_16070 putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); PFAM: Aldehyde Dehydrogenase; PRIAM: Succinate-semialdehyde dehydrogenase; SPTR: C1XQA8 Succinate semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; TIGRFAM: succinate-semialdehyde dehydrogenase.
   
 
 0.904
ADH63818.1
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR011603:IPR005475:IPR001017; KEGG: ttj:TTHA0289 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; PRIAM: Oxoglutarate dehydrogenase (succinyl-transferring); SMART: Transketolase central region; SPTR: C1XT57 2-oxoglutarate dehydrogenase E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
  
  
 0.850
ADH62549.1
COGs: COG0843 Heme/copper-type cytochrome/quinol oxidase subunit 1; InterPro IPR000298:IPR000883:IPR014241:IPR013833; KEGG: tth:TTC1671 cytochrome c oxidase polypeptide I+III; PFAM: cytochrome c oxidase subunit I; cytochrome c oxidase subunit III; PRIAM: Cytochrome-c oxidase; SPTR: C1XWH9 Cytochrome c oxidase, subunit I; TIGRFAM: cytochrome c oxidase, subunit I; PFAM: Cytochrome c oxidase subunit III; Cytochrome C and Quinol oxidase polypeptide I; TIGRFAM: cytochrome c oxidase, subunit I; Belongs to the heme-copper respiratory oxidase family.
   
  
 0.821
ADH62094.1
COGs: COG1485 ATPase; InterPro IPR005654; KEGG: tth:TTC1657 putative ATP/GTP-binding integral membrane protein; PFAM: AFG1-family ATPase; SPTR: C1XRS1 Predicted ATPase, COG1485; PFAM: AFG1-like ATPase.
 
     0.802
Your Current Organism:
Meiothermus silvanus
NCBI taxonomy Id: 526227
Other names: M. silvanus DSM 9946, Meiothermus silvanus ATCC 700542, Meiothermus silvanus DSM 9946, Meiothermus silvanus VI-R2, Meiothermus silvanus str. DSM 9946, Meiothermus silvanus strain DSM 9946
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